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Francis Crick 1916-2004
 


Country : Northampton, England
Profession : Scientist
Date of birth : 1916-06-08
Date of death : 2004-07-28
Cause of Death : Colon cancer

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crick

Francis Harry Compton Crick OM FRS (8 June 1916 – 28 July 2004), was a British molecular biologist, physicist, and neuroscientist, and most noted for being one of the co-discoverers of the structure of the DNA molecule in 1953. He, James D. Watson and Maurice Wilkins were jointly awarded the 1962 Nobel Prize for Physiology or Medicine "for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material" .

Crick is widely known for use of the term “central dogma” to summarize an idea that genetic information flow in cells is essentially one-way, from DNA to RNA to protein. Crick was an important theoretical molecular biologist and played a crucial role in research related to revealing the genetic code.

During the remainder of his career, he held the post of J.W. Kieckhefer Distinguished Research Professor at the Salk Institute for Biological Studies in La Jolla, California. His later research centered on theoretical neurobiology and attempts to advance the scientific study of human consciousness. He remained in this post until his death; "he was editing a manuscript on his death bed, a scientist until the bitter end" said Christof Koch.

Family and education

Francis Crick, the first son of Harry Crick (1887-1948) and Annie Elizabeth Crick(1879-1955), was born and raised in Weston Favell, then a small village near the English town of Northampton in which Crick’s father and uncle ran the family’s boot and shoe factory. His grandfather, Walter Drawbridge Crick (1857-1903), an amateur naturalist, wrote a survey of local foraminifera (single-celled protists with shells), corresponded with Charles Darwin, and had two gastropods (snails or slugs) named after him.

At an early age, Francis was attracted to science and what he could learn about it from books. As a child, he was taken to church by his parents, but by about age 12 he told his mother that he no longer wanted to attend, preferring a scientific search for answers over religious belief. He was educated at Northampton Grammar School and, after the age of 14, Mill Hill School in London (on scholarship), where he studied mathematics, physics, and chemistry with his best friend John Shilston. At the age of 21, Crick earned a B.Sc. degree in physics from University College of London (UCL) after he had failed to gain his intended place at a Cambridge college, probably through failing their requirement for Latin; his contemporaries in British DNA research Rosalind Franklin and Maurice Wilkins both went up to Cambridge colleges, to Newnham and St. John's respectively. Crick later became a PhD student and Honorary Fellow of Caius College and mainly worked at the Cavendish Laboratory and the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge. He was also an Honorary Fellow of Churchill College and of University College London.

Crick began a Ph.D. research project on measuring viscosity of water at high temperatures (what he later described as "the dullest problem imaginable) in the laboratory of physicist Edward Neville da Costa Andrade, but with the outbreak of World War II (in particular, an incident during the Battle of Britain when a bomb fell through the roof of the laboratory and destroyed his experimental apparatus), Crick was deflected from a possible career in physics.

During World War II, he worked for the Admiralty Research Laboratory, from which emerged a group of many notable scientists, including David Bates, Robert Boyd, George Deacon, John Gunn, Harrie Massey and Nevill Mott; he worked on the design of magnetic and acoustic mines and was instrumental in designing a new mine that was effective against German minesweepers.

After World War II, in 1947, Crick began studying biology and became part of an important migration of physical scientists into biology research. This migration was made possible by the newly won influence of physicists such as Sir John Randall, who had helped win the war with inventions such as radar. Crick had to adjust from the "elegance and deep simplicity" of physics to the "elaborate chemical mechanisms that natural selection had evolved over billions of years." He described this transition as, "almost as if one had to be born again." According to Crick, the experience of learning physics had taught him something important—hubris—and the conviction that since physics was already a success, great advances should also be possible in other sciences such as biology. Crick felt that this attitude encouraged him to be more daring than typical biologists who tended to concern themselves with the daunting problems of biology and not the past successes of physics.

For the better part of two years, Crick worked on the physical properties of cytoplasm at Cambridge's Strangeways Laboratory, headed by Honor Bridget Fell, with a Medical Research Council studentship, until he joined Max Perutz and John Kendrew at the Cavendish Laboratory. The Cavendish Laboratory at Cambridge was under the general direction of Sir Lawrence Bragg, who won the Nobel Prize in 1915 at the age of 25. Bragg was influential in the effort to beat a leading American chemist, Linus Pauling, to the discovery of DNA's structure (after having been 'pipped-at-the-post' by Pauling's success in determining the alpha helix structure of proteins). At the same time Bragg's Cavendish Laboratory was also effectively competing with King's College London, whose Biophysics department was under the direction of Sir John Randall. (Randall had turned down Francis Crick from working at King's College.) Francis Crick and Maurice Wilkins of King's College were personal friends, which influenced subsequent scientific events as much as the close friendship between Crick and James Watson. Crick and Wilkins first met at King's College and not, as erroneously recorded by two authors, at the Admiralty during World War II.

He married twice, was father to three children and grandfather to six grandchildren; his younger brother (Tony) had predeceased him in 1966:

  • Spouses: Ruth Doreen Crick, (b. 1913, m. 18 February 1940 – 8 May 1947); Odile Crick(b. 11 August 1920, m. 14 August 1949 – 28 July 2004, d. 5 July 2007)
  • Children: Michael (b. 25 November 1940) [by Doreen Crick]; Gabrielle (b. 15 July 1951) and Jacqueline [later Nichols] (b. 12 March 1954) [by Odile Crick];
  • Grandchildren: Alex (b. March 1974), Camberley (b. June 1978), Francis (b. February 1981), Kindra (b. May 1976),(Michael & Barbara Crick's children); Mark and Nicholas (Jacqueline Nichols' children).

Crick died of colon cancer on 28 July 2004 at the University of California San Diego (UCSD) Thornton Hospital in La Jolla]; he was cremated and his ashes were scattered into the Pacific Ocean. A public memorial was held on 27th of September 2004 at The Salk Institute, La Jolla, near San Diego, California; guest speakers included James D. Watson, Sydney Brenner, Alex Rich, the late Seymour Benzer, Aaron Klug, Christof Koch, Pat Churchland, Vilayanur Ramachandran, Tomaso Poggio, the late Leslie Orgel, Terry Sejnowski, his son Michael Crick, and his youngest daughter Jacqueline Nichols.  A more private memorial for family and colleagues had previously been held on 3rd of August 2004.

Biology research

Crick was interested in two fundamental unsolved problems of biology. First, how molecules make the transition from the non-living to the living, and second, how the brain makes a conscious mind. He realized that his background made him more qualified for research on the first topic and the field of biophysics. It was at this time of Crick’s transition from physics into biology that he was influenced by both Linus Pauling and Erwin Schrödinger. It was clear in theory that covalent bonds in biological molecules could provide the structural stability needed to hold genetic information in cells. It only remained as an exercise of experimental biology to discover exactly which molecule was the genetic molecule. In Crick’s view, Charles Darwin’s theory of evolution by natural selection, Gregor Mendel’s genetics and knowledge of the molecular basis of genetics, when combined, revealed the secret of life.

It was clear that some macromolecule such as protein was likely to be the genetic molecule. However, it was well-known that proteins are structural and functional macromolecules, some of which carry out enzymatic reactions of cells. In the 1940s, some evidence had been found pointing to another macromolecule, DNA, the other major component of chromosomes, as a candidate genetic molecule. In the 1944 Avery-MacLeod-McCarty experiment, Oswald Avery and his collaborators showed that a heritable phenotypic difference could be caused in bacteria by providing them with a particular DNA molecule.

However, other evidence was interpreted as suggesting that DNA was structurally uninteresting and possibly just a molecular scaffold for the apparently more interesting protein molecules. Crick was in the right place, in the right frame of mind, at the right time (1949), to join Max Perutz’s project at Cambridge University, and he began to work on the X-ray crystallography of proteins. X-ray crystallography theoretically offered the opportunity to reveal the molecular structure of large molecules like proteins and DNA, but there were serious technical problems then preventing X-ray crystallography from being applicable to such large molecules.

1949–1950

Crick taught himself the mathematical theory of X-ray crystallography. During the period of Crick's study of X-ray diffraction, researchers in the Cambridge lab were attempting to determine the most stable helical conformation of amino acid chains in proteins (the α helix). Linus Pauling was the first to identify the 3.6 amino acids per helix turn ratio of the α helix. Crick was witness to the kinds of errors that his co-workers made in their failed attempts to make a correct molecular model of the α helix; these turned out to be important lessons that could be applied, in the future, to the helical structure of DNA. For example, he learned the importance of the structural rigidity that double bonds confer on molecular structures which is relevant both to peptide bonds in proteins and the structure of nucleotides in DNA.

1951–1953: DNA structure

In 1951, together with William Gemmell Cochran and V. Vand, Crick assisted in the development of a mathematical theory of X-ray diffraction by a helical molecule. This theoretical result matched well with X-ray data obtained for proteins that contain sequences of amino acids in the Alpha helix conformation (published in Nature in 1952). Helical diffraction theory turned out to also be useful for understanding the structure of DNA.

Late in 1951, Crick started working with James D. Watson at Cavendish Laboratory at the University of Cambridge, England. Using "Photo 51" (the X-ray diffraction results of Raymond Gosling and Rosalind Franklin of King's College London, given to them by Gosling and Franklin's colleague Maurice Wilkins), Watson and Crick together developed a model for a helical structure of DNA, which they published in 1953. For this and subsequent work they were jointly awarded the Nobel Prize in Physiology or Medicine in 1962 with Maurice Wilkins.

When James Watson came to Cambridge, Crick was a 35-year-old post-graduate student (due to his work during WWII) and Watson was only 23, but he already had a Ph.D. They shared an interest in the fundamental problem of learning how genetic information might be stored in molecular form. Watson and Crick talked endlessly about DNA and the idea that it might be possible to guess a good molecular model of its structure. A key piece of experimentally-derived information came from X-ray diffraction images that had been obtained by Maurice Wilkins, Rosalind Franklin, and their research student, Raymond Gosling. In November 1951, Wilkins came to Cambridge and shared his data with Watson and Crick. Alexander Stokes (another expert in helical diffraction theory) and Wilkins (both at King's College) had reached the conclusion that X-ray diffraction data for DNA indicated that the molecule had a helical structure—but Franklin vehemently disputed this conclusion. Stimulated by their discussions with Wilkins and what Watson learned by attending a talk given by Franklin about her work on DNA, Crick and Watson produced and showed off an erroneous first model of DNA. Their hurry to produce a model of DNA structure was driven in part by Watson's belief that they were competing against Linus Pauling. Given Pauling's recent success in discovering the Alpha helix, it was not unreasonable to worry that Pauling might also be the first to determine the structure of DNA.

Many have speculated about what might have happened had Pauling been able to travel to Britain as planned in May 1952. He might have been invited to see some of the Wilkins/Franklin X-ray diffraction data, and such an event might have led him to a double helix model (which remains—as said above—total speculation). As it was, his political activities caused his travel to be restricted by the U. S. government and he did not visit the UK until later, at which point he met none of the DNA researchers in England—but at any rate he was preoccupied with proteins at the time, not DNA. Watson and Crick were not officially working on DNA. Crick was writing his Ph.D. thesis; Watson also had other work such as trying to obtain crystals of myoglobin for X-ray diffraction experiments. In 1952, Watson did X-ray diffraction on tobacco mosaic virus and found results indicating that it had helical structure. Having failed once, Watson and Crick were now somewhat reluctant to try again and for a while they were forbidden to make further efforts to find a molecular model of DNA.

Of great importance to the model building effort of Watson and Crick was Rosalind Franklin's understanding of basic chemistry, which indicated that the hydrophilic phosphate-containing backbones of the nucleotide chains of DNA should be positioned so as to interact with water molecules on the outside of the molecule while the hydrophobic bases should be packed into the core. Franklin shared this chemical knowledge with Watson and Crick when she pointed out to them that their first model (from 1951, with the phosphates inside) was obviously wrong.

Crick described what he saw as the failure of Maurice Wilkins and Rosalind Franklin to cooperate and work towards finding a molecular model of DNA as a major reason why he and Watson eventually made a second attempt to do so. They asked for, and received, permission to do so from both William Lawrence Bragg and Wilkins. In order to construct their model of DNA, Watson and Crick made use of information from unpublished X-ray diffraction images of Franklin's (shown at meetings and freely shared by Wilkins), including preliminary accounts of Franklin's results/photographs of the X-ray images that were included in a written progress report for the King's College laboratory of Sir John Randall from late 1952.

It is a matter of debate whether Watson and Crick should have had access to Franklin's results without her knowledge or permission, and before she had had a chance to formally publish the results of her detailed analysis of her X-ray diffraction data which were included in the progress report. However, Watson and Crick found fault in her steadfast assertion that, according to her data, a helical structure was not the only possible shape for DNA—so they had a dilemma. In an effort to clarify this issue, Max Ferdinand Perutz later published what had been in the progress report, and suggested that nothing was in the report that Franklin herself had not said in her talk (attended by Watson) in late 1951. Further, Perutz explained that the report was to a Medical Research Council (MRC) committee that had been created in order to "establish contact between the different groups of people working for the Council". Randall's and Perutz's laboratories were both funded by the MRC.

It is also not clear how important Franklin's unpublished results from the progress report actually were for the model-building done by Watson and Crick. After the first crude X-ray diffraction images of DNA were collected in the 1930s, William Astbury had talked about stacks of nucleotides spaced at 3.4 angström (0.34 nanometre) intervals in DNA. A citation to Astbury's earlier X-ray diffraction work was one of only eight references in Franklin's first paper on DNA. Analysis of Astbury's published DNA results and the better X-ray diffraction images collected by Wilkins and Franklin revealed the helical nature of DNA. It was possible to predict the number of bases stacked within a single turn of the DNA helix (10 per turn; a full turn of the helix is 27 angströms [2.7 nm] in the compact A form, 34 angströms [3.4 nm] in the wetter B form). Wilkins shared this information about the B form of DNA with Crick and Watson. Crick did not see Franklin's B form X-ray images until after the DNA double helix model was published.

One of the few references cited by Watson and Crick when they published their model of DNA, was to a published article that included Sven Furberg's DNA model that had the bases on the inside. Thus, the Watson and Crick model was not the first "bases in" model to be published. Furberg's results had also provided the correct orientation of the DNA sugars with respect to the bases. During their model building, Crick and Watson learned that an anti-parallel orientation of the two nucleotide chain backbones worked best to orient the base pairs in the centre of a double helix. Crick's access to Franklin's progress report of late 1952 is what made Crick confident that DNA was a double helix with anti-parallel chains, but there were other chains of reasoning and sources of information that also led to these conclusions.

As a result of leaving King's College for another institution, Franklin was asked by John Randall to give up her work on DNA. When it became clear to Wilkins and the supervisors of Watson and Crick that Franklin was going to the new job, and that Linus Pauling was working on the structure of DNA, they were willing to share Franklin's data with Watson and Crick, in the hope that they could find a good model of DNA before Pauling was able. Franklin's X-ray diffraction data for DNA and her systematic analysis of DNA's structural features was useful to Watson and Crick in guiding them towards a correct molecular model. The key problem for Watson and Crick, which could not be resolved by the data from King's College, was to guess how the nucleotide bases pack into the core of the DNA double helix.

Another key to finding the correct structure of DNA was the so-called Chargaff ratios, experimentally determined ratios of the nucleotide subunits of DNA: the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine. A visit by Erwin Chargaff to England in 1952 reinforced the salience of this important fact for Watson and Crick. The significance of these ratios for the structure of DNA were not recognized until Watson, persisting in building structural models, realized that A:T and C:G pairs are structurally similar. In particular, the length of each base pair is the same. The base pairs are held together by hydrogen bonds, the same non-covalent interaction that stabilizes the protein α-helix. Watson's recognition of the A:T and C:G pairs was aided by information from Jerry Donohue about the most likely structures of the nucleobases. After the discovery of the hydrogen bonded A:T and C:G pairs, Watson and Crick soon had their double helix model of DNA with the hydrogen bonds at the core of the helix providing a way to "unzip" the two complementary strands for easy replication: the last key requirement for a likely model of the genetic molecule. As important as Crick's contributions to the discovery of the double helical DNA model were, he stated that without the chance to collaborate with Watson, he would not have found the structure by himself.

 

The discovery was made on February 28, 1953; the first Watson/Crick paper appeared in Nature on April 25,1953. Sir Lawrence Bragg, the director of the Cavendish Laboratory, where Watson and Crick worked, gave a talk at Guys Hospital Medical School in London on Thursday, May 14, 1953 which resulted in an article by Ritchie Calder in The News Chronicle of London, on Friday, May 15, 1953, entitled "Why You Are You. Nearer Secret of Life." The news reached readers of The New York Times the next day; Victor K. McElheny, in researching his biography, "Watson and DNA: Making a Scientific Revolution", found a clipping of a six-paragraph New York Times article written from London and dated May 16, 1953 with the headline "Form of `Life Unit' in Cell Is Scanned." The article ran in an early edition and was then pulled to make space for news deemed more important.(The New York Times subsequently ran a longer article on June 12, 1953). The Cambridge University undergraduate newspaper Varsity also ran its own short article on the discovery on Saturday, May 30th, 1953. Bragg's original announcement of the discovery at a Solvay conference on proteins in Belgium on 8 April 1953 went unreported by the British press!

Molecular biology

In 1954, at the age of 37, Crick completed his Ph.D. thesis: "X-Ray Diffraction: Polypeptides and Proteins" and received his degree. Crick then worked in the laboratory of David Harker at Brooklyn Polytechnic Institute, where he continued to develop his skills in the analysis of X-ray diffraction data for proteins, working primarily on ribonuclease and the mechanisms of protein synthesis. David Harker, the American X-ray crystallographer, was described as "the John Wayne of crystallography" by Vittorio Luzzati, a crystallographer at the Centre for Molecular Genetics in Gif-sur-Yvette near Paris, who had worked with Rosalind Franklin.

After the discovery of the double helix model of DNA, Crick's interests quickly turned to the biological implications of the structure. In 1953, Watson and Crick published another article in Nature which stated: "it therefore seems likely that the precise sequence of the bases is the code that carries the genetical information".

In 1956, Crick and Watson speculated on the structure of small viruses. They suggested that spherical viruses such as Tomato bushy stunt virus had icosahedral symmetry and were made from 60 identical subunits.

After his short time in New York, Crick returned to Cambridge where he worked until 1976, at which time he moved to California. Crick engaged in several X-ray diffraction collaborations such as one with Alexander Rich on the structure of collagen. However, Crick was quickly drifting away from continued work related to his expertise in the interpretation of X-ray diffraction patterns of proteins.

George Gamow established a group of scientists interested in the role of RNA as an intermediary between DNA as the genetic storage molecule in the nucleus of cells and the synthesis of proteins in the cytoplasm. It was clear to Crick that there had to be a code by which a short sequence of nucleotides would specify a particular amino acid in a newly synthesized protein. In 1956, Crick wrote an informal paper about the genetic coding problem for the small group of scientists in Gamow's RNA group. In this article, Crick reviewed the evidence supporting the idea that there was a common set of about 20 amino acids used to synthesize proteins. Crick proposed that there was a corresponding set of small "adaptor molecules" that would hydrogen bond to short sequences of a nucleic acid, and also link to one of the amino acids. He also explored the many theoretical possibilities by which short nucleic acid sequences might code for the 20 amino acids.

Controversy about using King's College London's results

An enduring controversy has been generated by Watson and Crick's use of DNA X-ray diffraction data collected by Rosalind Franklin and her student Raymond Gosling. The controversy arose from the fact that some of the data were shown to them, without her knowledge, by Maurice Wilkins and Max Perutz. Her experimental results provided estimates of the water content of DNA crystals, and these results were most consistent with the three sugar-phosphate backbones being on the outside of the molecule. Franklin personally told Crick and Watson that the backbones had to be on the outside, whilst vehemently stating that her data did not force one to conclude that DNA has a helical structure. Her identification of the space group for DNA crystals revealed to Crick that the DNA strands were antiparallel, which helped Watson and Crick decide to look for DNA models with two antiparallel polynucleotide strands. The X-ray diffraction images collected by Franklin provided the best evidence for the helical nature of DNA—but she failed to recognise this fact. However Franklin's experimental work proved important in Crick and Watson's development of the correct model.

Prior to publication of the double helix structure, Watson and Crick had little interaction with Franklin. Crick and Watson felt that they had benefited from collaborating with Maurice Wilkins. They offered him a co-authorship on the article that first described the double helix structure of DNA. Wilkins turned down the offer, and was in part responsible for the terse character of the acknowledgment of experimental work done at King's College London. Rather than make any of the DNA researchers at King's College co-authors on the Watson and Crick double helix article, the solution was to publish two additional papers from King's College along with the helix paper. Brenda Maddox suggested that because of the importance of her experimental results in Watson and Crick's model building and theoretical analysis, Franklin should have had her name on the original Watson and Crick paper in Nature. Franklin and Gosling submitted their own joint 'second' paper to Nature at the same time as Wilkins, Stokes, and Wilson submitted theirs (i.e. the 'third' paper on DNA).

Directed panspermia

During the 1960s, Crick became concerned with the origins of the genetic code. In 1966, Crick took the place of Leslie Orgel at a meeting where Orgel was to talk about the origin of life. Crick speculated about possible stages by which an initially simple code with a few amino acid types might have evolved into the more complex code used by existing organisms. At that time, everyone thought of proteins as the only kind of enzymes and ribozymes had not yet been found. Many molecular biologists were puzzled by the problem of the origin of a protein replicating system that is as complex as that which exists in organisms currently inhabiting Earth. In the early 1970s, Crick and Orgel further speculated about the possibility that the production of living systems from molecules may have been a very rare event in the universe, but once it had developed it could be spread by intelligent life forms using space travel technology, a process they called “Directed Panspermia”. In a retrospective article, Crick and Orgel noted that they had been overly pessimistic about the chances of abiogenesis on Earth when they had assumed that some kind of self-replicating protein system was the molecular origin of life. Crick addressed the Origin of Protein Synthesis in a famous paper with 3 independent Nobel laureates, including Sydney Brenner and Aaron Klug and Prof. Pieczenik. In this paper, based on Prof. Pieczenik's work, they speculate that code constraints on nucleotide sequences allow protein synthesis without the need for a ribosome. It, however, requires a five base binding between the mRNA and tRNA with a flip of the anti-codon creating a triplet coding, even though it is a five base physical interaction. Jukes pointed out that the code constraints on the mRNA sequence required for this translation mechanism is still preserved suggesting that Pieczenik's Genotypic Selection model for translation is a contemporary constraint and not just a historical constraint imposed on coding. Prof. Pieczenik's work was original sent to be reviewed for PNAS by Norton Zinder and later appeared as part of Francis Crick's work. Rollin Hotchkiss, the fourth man in the Avery, McCleod and McCarty team, showing DNA was the genetic material submitted Prof.Pieczenik's work to PNAS as The Theory of Genotypic Selection.

Recognition

In addition to the 1962 Nobel prize he received many awards and honours, including the Royal and Copley medals of the Royal Society (1972 and 1975), and also the Order of Merit (November 27 1991); he refused an offer of a CBE in 1963 and later refused an offer of a knighthood, but was often referred to in error as 'Sir Francis Crick' and even on occasions as 'Lord Crick'; Richard Lewontin's review of The Double Helix by James Watson in "The Chicago Sunday Times" on February 25 1968 contained an astonishing four references to "Sir Francis Crick" - in error.

On Saturday, October 20 1962 the award of Nobel prizes to John Kendrew and Max Perutz, and to Crick, Watson, and Wilkins was satirised in a short sketch in the BBC TV programme That Was The Week That Was with the Nobel Prizes being referred to as 'The Alfred Nobel Peace Pools.'

The Francis Crick Prize Lectures at The Royal Society, London

The Francis Crick Prize Lecture was established in 2003 following an endowment by his former colleague, Sydney Brenner, joint winner of the 2002 Nobel Prize in Physiology and Medicine. The lecture is delivered annually in any field of biological sciences, with preference given to the areas in which Francis Crick himself worked. Importantly, the lectureship is aimed at younger scientists, ideally under 40, or whose career progression corresponds to this age.

The Francis Crick Graduate Lectures at the University of Cambridge

The University of Cambridge Graduate School of Biological, Medical and Veterinary Sciences hosts The Francis Crick Graduate Lectures. The first two lectures were by John Gurdon and Tim Hunt.

"For my generation, Francis Crick was probably the most obviously influential presence. He was often at lunch in the canteen of the Laboratory of Molecular Biology where he liked to explain what he was thinking about, and he was always careful to make sure that everyone round the table really understood. He was a frequent presence at talks in and around Cambridge, where he liked to ask questions. Sometimes, I remember thinking, they seemed slightly ignorant questions to which a man of his extraordinary range and ability ought to have known the answers. Only slowly did it dawn on me that he only and always asked questions when he was unclear or unsure, a great lesson." (Tim Hunt, first Francis Crick Graduate Lecturer: June 2005)

Books by Francis Crick

  • Of Molecules and Men (Prometheus Books, 2004; original edition 1967) Life Itself (Simon & Schuster, 1981)
  • What Mad Pursuit: A Personal View of Scientific Discovery (Basic Books reprint edition, 1990)
  • The Astonishing Hypothesis: The Scientific Search For The Soul (Scribner reprint edition, 1995)
  • Kreiseliana: about and around Georg Kreisel; 495 pages. For pages 25 - 32 "Georg Kreisel: a Few Personal Recollections" contributed by Francis Crick.

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